Charnock52 stated that renal rickets is a disease of childhood in which chronic renal insufficiency is associated with osseous changes closely resembling those of late rickets. The clinical picture is that of a stunted, deformed child suffering from diminished renal function, severe acidosis and altered calcium-phosphorus metabolism.The renal lesions present a wide variety of conditions with reduction in functioning tissue the predominating picture.The bone changes affect principally the regions of the growth disks, with a general tendency to osteoporosis. The picture is one of calcium deficiency.Three etiologic theories are discussed: 1. The renal theory, which supposes that the waste phosphates ordinarily found in the urine may be excreted into the intestines and that these can interfere with the absorption of calcium by the formation of insoluble calcium phosphates. 2. The theory that parathyroid hypertrophy is compensatory to the high level of blood phosphorus and
SCHOLL AJ, HINMAN F, von LICHTENBERG A, et al. REVIEW OF UROLOGIC SURGERY. Arch Surg. 1941;43(2):306–325. doi:10.1001/archsurg.1941.01210140140011
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