In 1928, Ewing1 defined multiple myeloma as... a specific malignant tumor of the bone marrow arising probably from a single cell-type and characterized chiefly by multiple foci of origin, a uniform and specific structure composed of plasma cells or their derivatives, rare metastases, albumosuria and fatal termination.
Vance,2 considering the disease more from the clinical than from the pathologic standpoint, described multiple myeloma as characterized by... multiple primary tumors of the bone marrow, occurring, for the most part, in elderly individuals, and manifested during life by deep-seated pain in the bones, characteristic deformities of the skeleton, spontaneous fractures in many bones of the body, severe secondary anemia, and emaciation.
Geschickter and Copeland3 emphasized that the... disease not only produces extensive involvement of the skeleton, but the systemic manifestations are particularly widespread and that changes in the central nervous system, the thorax, the lungs, the kidneys and in
DONHAUSER JL, de ROUVILLE WH. MULTIPLE MYELOMA, WITH SPECIAL REFERENCE TO SOFT TISSUE METASTASIS. Arch Surg. 1941;43(6):946–1020. doi:10.1001/archsurg.1941.01210180015002
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