The bacteriostatic effects of sulfanilamide and its various derivatives are now too well known to require comment, and the rationale of the local use of these drugs in wounds has recently been reviewed by Key and Frankel.1 Consequently, in this paper no attempt will be made to review the literature either on the effects of the drugs on various types of bacteria or on whether they are of value in combating infection when used locally in wounds. It is, however, a matter of growing interest to know whether or not the introduction of these drugs will inhibit the process of wound healing or will lead to the formation of adhesions in the peritoneum. This matter becomes especially important when one considers two stage procedures within the abdominal cavity; the difficulty encountered is often dependent on the presence of firm peritoneal adhesions.
It was noted by Key and Burford2
HARBISON SP, KEY JA. LOCAL IMPLANTATION OF SULFANILAMIDE AND ITS DERIVATIVES IN WOUNDSITS RELATION TO WOUND HEALING AND TO PERITONEAL ADHESIONS. Arch Surg. 1942;44(1):22–26. doi:10.1001/archsurg.1942.01210190025002
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