The literature on the effect of the vitamin B complex on wound healing is confined to observations on surface healing and is summarized by Arey1 in his article on wound healing. Saitta2 found that a deficiency in the vitamin B complex resulted in diminished power of cicatrization in wounds of the skin, the subcutaneous tissue and the muscles. Oral administration of extract of cereals prevented these changes, and direct treatment of the wounds with the vitamin B complex produced normal activation of the cellular repair. Lauber3 emphasized the unreliability of results obtained with the vitamin B complex and attributed this to a lack of standardization of the exact amounts of the vitamin in vitamin B-rich diets. He found no difference in wound healing between control animals and animals fed with yeast. Larcher4 found that wounds in pigeons suffering from a deficiency of the vitamin B complex
HOLDEN JC, CRILE G. INFLUENCE OF VITAMIN B COMPLEX DEFICIENCY AND PARTIAL STARVATION ON WOUND HEALING: EXPERIMENTAL RESEARCH WITH RATS. Arch Surg. 1942;44(6):1106–1110. doi:10.1001/archsurg.1942.01210240145011
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