In view of the frequent association of varicose veins of the extremities with trophic changes in the skin, it becomes important to ascertain the state of the circulation in the former condition. Using the same patient, de Takáts and his associates1 compared the gaseous content of venous blood from a normal upper extremity with that from a lower extremity with varicose veins and found a uniform increase in carbon dioxide and a decrease in oxygen content in the sample obtained from the lower limb. A similar procedure in a group of normal subjects revealed no such difference, at least as far as carbon dioxide content was concerned. On the basis of these results, the authors concluded that the tissues of a leg with varicosities are in a state of chronic anoxemia. According to them, this factor together with the retention of carbon dioxide and other waste products is responsible
ABRAMSON DI, FIERST SM. ARTERIAL BLOOD FLOW IN EXTREMITIES WITH VARICOSE VEINS. Arch Surg. 1942;45(6):964–968. doi:10.1001/archsurg.1942.01220060103008
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