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June 1943


Author Affiliations

Passed Assistant Surgeon (R), United States Public Health Service BETHESDA, MD.
From the National Cancer Institute, National Institute of Health, United States Public Health Service.

Arch Surg. 1943;46(6):793-806. doi:10.1001/archsurg.1943.01220120002001

INTRODUCTION  This review reconsiders the basis on which experimental gastric cancer has been produced. Briefly it points out the peculiarities of the human gastric mucosa and compares it with that of other species. The recognized precancerous conditions of the mucosa are then described, and special consideration is given to the concept of the possible origin of gastric cancer from a chronically damaged mucosa. The multiplicity of factors, secondary, environmental or hereditary, which might produce this alteration are considered. No claim is made for causal connection. Possible points for experimental attack are discussed.Its inaccessibility has gained for gastric cancer a certain element of mystery which has tended to set it apart from other forms of neoplasia. Yet when the severely altered structural background out of which gastric cancer arises is understood it is apparent that its origin is not particularly different from that of other carcinomas, for instance cutaneous cancer

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