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Article
May 1944

ORAL ADMINISTRATION OF DIETHYLSTILBESTROL FOR PROSTATISM: A CLINICAL EVALUATION

Author Affiliations

NEW YORK
From the Surgical Division of the Hospital and Home of the Daughters of Jacob.

Arch Surg. 1944;48(5):381-387. doi:10.1001/archsurg.1944.01230010392005
Abstract

A frequent and persistent complaint of the aged man is inability to rest at night due to frequent urination. In our institution, we have an opportunity to observe over 200 men whose ages range from 67 to 98 years. Many of these men are unwilling to undergo prostatectomy or are poor risks for such a procedure. Hence we have attempted to alleviate their condition by the oral administration of diethylstilbestrol.

Noble,1 soon after the effects of diethylstilbestrol had been noted, reported that male rats after treatment with diethylstilbestrol exhibit atrophy of the testicle and decrease in the size of the seminal vesicles and the prostate. Mellish, Baer and Macias,2 using an experimental group of 39 rats which had received implantations of 10 mg. of diethylstilbestrol twenty-eight days previous to autopsy, found the mean weight of the prostate to be 20 mg. In an untreated group of 23 controls,

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