HISTORY AND PURPOSE
As early as 1895 Leube1 raised the question of subcutaneous injections of fat for nutritional purposes, in connection with administration of repeated injections of camphor oil to patients with cardiac failure. Attempts were made by a number of workers2 to study utilization of subcutaneously injected fat, although absorption from the sites of the injections was admittedly relatively slow. Studies on the utilization of emulsions of fats administered by vein to animals were made by Murlin and Riche in 1915,3 Nomura in 1929,4a Baba in 19315 and Narat in 1937.6a,b It was reported that by such injections the lives of 2 starving dogs were prolonged6a, b and in rabbits the iodine and saponification numbers of body fats were altered in the direction of those of the infused fats.4b While it was suggested that the infused fat was deposited in the
DUNHAM LJ, BRUNSCHWIG A. INTRAVENOUS ADMINISTRATION OF FAT FOR NUTRITIONAL PURPOSES: EXPERIMENTAL STUDY. Arch Surg. 1944;48(5):395–405. doi:10.1001/archsurg.1944.01230010406007
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