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Article
June 1944

REGIONAL ENTERITIS: PATHOLOGIC STUDY OF TWENTY-TWO CASES

Arch Surg. 1944;48(6):465-471. doi:10.1001/archsurg.1944.01230010478007
Abstract

The condition known as "regional enteritis" was first established as an entity by Crohn, Ginzburg and Oppenheimer 1 in 1932. It has been variously referred to since that time as "terminal ileitis," "regional ileitis" and "regional enteritis." The last term is that most commonly accepted at the present time, for the disease is not confined to the ileum but may involve any portion of the small bowel and even the large bowel.

Crohn and his collaborators emphasized the occurrence of different stages or phases of regional enteritis, which they characterized as (1) the acute inflammatory phase, (2) the ulcerative phase, (3) the stenotic phase and (4) the phase of formation of fistulas. The first two might be referred to as acute stages and the last two as chronic. However, an important gross differential feature is the patchy or segmental involvement of the bowel. It should be emphasized that lesions of

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