During 1944 there were comparatively few articles on the subject of tuberculosis of bones and joints of sufficient interest to include in a review of progress. However, it is encouraging to note an increase in experimental studies toward developing inhibiting or bacteriostatic agents that may be effective against tuberculosis. The effect of a number of sulfonamide compounds, including Diasone and promin, has been studied by a number of investigators, both in the laboratory and on human patients. The results appear to justify the hope that some important result may be expected, although the subject still is in the experimental stage.
In a study by and Prenzlau,178 Diasone (disodium formaldehyde sulfoxylate diaminodiphenyl sulfone) was therapeutically administered to 78 tuberculous patients for periods ranging from sixty to two hundred and seventyfive days. Seventy-two of the patients had pulmonary lesions, 5 had lesions of bones and joints and 1 had genitourinary lesions.