THIS is a report of a study conducted on 575 patients in the surgical service of the Louisville General Hospital to determine the effectiveness of a relatively new germicide, cetylpyridinium chloride, as a cutaneous antiseptic. It was compared with other germicides used as cutaneous antiseptics in major surgical procedures for routine preoperative preparation. The germicides used for comparison were selected as to type of compound and represented a mercurial, a combined cresol and mercurial and a cationic detergent.
OBJECTIVE OF THE STUDY
In conducting a study of the relative value of any chemical germicide to be used for cutaneous antisepsis immediately prior to operation, we recognized that the structure of the skin itself is such that its complete sterilization is impossible. The chief objective in preoperative preparation is actually a reduction in the number of pathogenic bacteria, or a quanitative and qualitative "degerming." Most of the published reports of studies
HAGAN HH, MAGUIRE CH, MILLER WH. CETYLPYRIDINIUM CHLORIDE AS A CUTANEOUS GERMICIDE IN MAJOR SURGERY: A Comparative Study. Arch Surg. 1946;52(2):149–159. doi:10.1001/archsurg.1946.01230050153003
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