In A PREVIOUS paper,1 one of us (J. K. B.) reported the results of experimental studies on burn shock when treated with isotonic solution of sodium chloride injected by hypodermoclysis into the burned area. These studies revealed the following significant facts: 1. There is a loss of water and electrolytes, chiefly salt, followed by plasma proteins into the burned area. 2. This loss continues until pressure in the tissue spaces equals the hydrostatic pressure within the capillaries. Then reabsorption begins but in the reverse manner. That is, colloids are returned first by the lymphatic vessels, which behave as a semipermeable membrane. Then crystalloids are absorbed by the capillaries. 3. The loss of plasma occurs earlier in the more severely (third degree) than in the less severely burned animals. 4. Treatment by hypodermoclysis of isotonic solution of sodium chloride into the burned area seems to decrease the amount of water
BERMAN JK, PIERCE GS, BEST MM. BURN SHOCK: Its Treatment with Continuous Hypodermoclysis of Isotonic Solution of Sodium Chloride Into the Burned Areas; Clinical Studies in Two Cases. Arch Surg. 1946;53(5):577–587. doi:10.1001/archsurg.1946.01230060587006
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