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December 1946

HIGH PROTEIN THERAPY: Clinical Effectiveness of Oral Administration of a New Protein Preparation As Determined by Nitrogen Balance Studies

Author Affiliations

Abbott Fellow in Surgery, Northwestern University Medical School; CHICAGO
From the Hektoen Institute for Medical Research of the Cook County Hospital and the departments of surgery of the Cook County Hospital, Northwestern University Medical School and the Cook County Graduate School of Medicine.

Arch Surg. 1946;53(6):683-701. doi:10.1001/archsurg.1946.01230060694008

IN A RECENTLY reported study from this laboratory,1 it was shown that positive nitrogen balances could be consistently obtained in surgical patients with protein deficiency by the parenteral administration of amino acids as the only source of nitrogen. However, this method was not successful as a practical program for restoration of the large losses of nitrogen incurred in the protracted deficiency of protein of such patients. With nitrogen losses estimated to be on the order of 480 Gm., the average positive nitrogen balance of 4 Gm. that was obtained would require one hundred and twenty days of continuous intravenous treatment for complete restitution of protein stores. Such management was obviously impractical if not impossible. The time required could be reduced, it was true, if parenteral injections were supplemented with blood transfusions and with normal oral alimentation.

The need for high intakes of protein or protein digests in patients with

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