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Article
November 1947

SOME PHYSIOLOGIC AND BIOCHEMICAL ALTERATIONS INCIDENT TO SURGICAL INTERVENTION: Report of a Case

Arch Surg. 1947;55(5):624-631. doi:10.1001/archsurg.1947.01230080633011
Abstract

THE SURGEON is often presented with a deranged metabolism in patients who have undergone surgical treatment. The derangement may be due to the damaging effects of the operation itself or to a combination of the basic disease process, the operation and other complicating factors such as starvation or salt imbalance. Although knowledge of the metabolic disturbances which take place after operative procedures is admittedly highly important, the literature on this subject is fragmentary and incomplete. As a rule, only a few aspects of the physiologic process in the patient have been studied, such as organic function or tissue electrolytes, and then only in complicated cases. Accordingly, it was felt desirable to make as thorough a study as possible of the physiologic and biochemical changes which take place during and after operation.

The selection of the patient for a composite study of this type was an important consideration. Such a patient

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