ARMSTRONG730 states the opinion that paralysis of an extremity beginning at an early age frequently results in disturbance of bone growth. Several experimental studies on dogs are mentioned; in these it was indicated that with growth the bone of a paralyzed limb continues to gain in mass, but at a rate lower than normal. He cites several experiments by other investigators, using rats and dogs in which the brachial plexus had been severed. Shortening of bone and atrophy occurred in all the experimental animals, to varied degrees. Armstrong's own experiment on large rats, also performed after the brachial plexus had been severed, indicated that (1) the growth in length of the radius was affected earlier, and to a greater degree, than that of the humerus; (2) the reduction of growth in diameter of the humerus was greater than the reduction of growth in length; (3) the growth in diameter
IRWIN CE. PROGRESS IN ORTHOPEDIC SURGERY FOR 1946 A Review Prepared by an Editorial Board of the American Academy of Orthopaedic Surgeons: XVI. INFANTILE PARALYSIS. Arch Surg. 1949;58(4):561–564. doi:https://doi.org/10.1001/archsurg.1949.01240030569016
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