CHRONIC traumatic osteomyelitis following injuries of long bones sustained in World War II was one of the most serious problems confronting the army general hospital one year after the cessation of hostilities. At Oliver General Hospital over 300 patients with chronic osteomyelitis were treated from Oct. 1, 1946 to Jan. 1, 1948. Various principles of conservative and surgical management1 evolved from World War I to the present were applied, with uniformly good results.2 However, in spite of diligent measures, infection persisted in certain refractory cases. In the present study of 26 such cases, all cases of united fractures, we sought to evaluate the effectiveness of streptomycin with or without the combination of penicillin.3 Four cases of infection following bone graft and 1 case of chronic hematogenous osteomyelitis were also added. In this series, the average duration of infection was 26.2 months and an average of 3.6 sequestrectomies
SMITH WS, GANEY JB. STREPTOMYCIN IN CHRONIC TRAUMATIC OSTEOMYELITIS. Arch Surg. 1950;60(1):125–142. doi:10.1001/archsurg.1950.01250010141013
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