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July 1950

INFLUENCE OF VAGOTOMY ON PEPTIC ULCER, GASTRIC ACIDITY AND MOTILITY: A Follow-Up Study on Sixty-Eight Patients and Evaluation of the Operation

Author Affiliations

Fellow in Surgery, Mayo Foundation ROCHESTER, MINN.
From the Division of Surgery, Mayo Clinic.

Arch Surg. 1950;61(1):86-94. doi:10.1001/archsurg.1950.01250020089010

ON DEC. 6, 1946, one of us (Walters) presented before this society a paper on the anatomic distribution of the vagus nerves at the lower end of the esophagus, with a brief report on 66 patients who had undergone vagotomy at the Mayo Clinic. Thirty-three of the operations had been performed by one of us (Walters) and 33 by other surgeons. In that paper1 the following statements were made:

... because of the experimental evidence [Hartzel and Vanzant] that the changes in gastric acidity and motility after vagotomy may be only temporary, and because long experience with peptic ulcer makes us reserve our judgment concerning any operation until a large series of patients have been watched for many years, gastric neurectomy [vagotomy] is being performed at the Mayo Clinic in selected cases of peptic ulcer only. We think that the final report of this operation is not due for several