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October 1950

ARTERIAL HOMOGRAFTS: II. Resection of Thoracic Aortic Aneurysm Using a Stored Human Arterial Transplant

Author Affiliations

From the departments of surgery and physiology, and the Cardiovascular-Pulmonary Research Laboratory, University of Colorado School of Medicine.

AMA Arch Surg. 1950;61(4):732-737. doi:10.1001/archsurg.1950.01250020738013

THE PROBLEM of bridging a large gap in a major artery has long been one of importance to both the civilian and the military surgeon. Peirce and his co-workers1 have recently reintroduced interest in the use of stored arterial homografts for this purpose. In their preliminary studies on dogs these workers demonstrated that such homografts, if taken aseptically within the first few hours after death of the donor animal, could be stored in a standard refrigerator when placed in buffered salt solution containing 10 per cent dog serum. When transplanted into a recipient animal after storage up to fifty days, these homografts would function successfully as a conduit of blood for periods longer than a year. A high percentage of successful "takes" could be obtained by careful anastomotic technics. In addition, it was shown by tissue culture methods that "viable" cells persisted in the stored vessels up to forty

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