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December 1950

ISLET CELL ADENOMA: Three Cases, One Extrapancreatic, Cured by Operation

Author Affiliations

From the Pfeiffer Surgical Clinic, Abington Memorial Hospital.

AMA Arch Surg. 1950;61(6):1096-1102. doi:10.1001/archsurg.1950.01250021106011

SINCE Roscoe Graham1 first successfully diagnosed and extirpated an islet cell adenoma of the pancreas in 1929, this entity of hyperinsulinism due to adenoma has been well recognized and successfully treated. McClure and Brush2 report that approximately 140 patients have been successfully operated on for this condition, but there appear in the literature only 5 cases of functioning extrapancreatic islet tumors causing hyperinsulinism. To these totals we should like to add three cases, in one of which the adenoma was extrapancreatic in location.

Case 1.  —M. J., a white woman aged 64, first came under observation in 1936 when she was admitted to Abington Memorial Hospital complaining of double vision of 18 months' duration, fainting spells and dizziness. She obtained partial relief with the ingestion of sugar. Her glucose tolerance curve on several occasions when she was admitted to the hospital led to a tentative diagnosis of hyperinsulinism,

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