SINCE pulmonary edema was first described by Maloet in 1752,1 there has been a great deal of clinical and experimental investigation into the problem to elucidate the factors which may be involved in the production of the syndrome. Studies have seldom been made during and after the development of severe pulmonary edema.
For such experiments it is necessary to have a rapid, standard method for the production of pulmonary edema in a fairly large animal which will produce edema in a high percentage of the animals subjected to the procedure. The method employed should produce no physiological alteration which is not likely to be found in human beings with pulmonary edema, and it should not involve any procedure which in itself is likely to cause the death of the animal.
A review of the literature reveals that the following methods have been used for the production of pulmonary edema
JORDAN GL, DeLANEY AY. STANDARD METHOD FOR THE PRODUCTION OF PULMONARY EDEMA IN THE DOG. AMA Arch Surg. 1951;63(2):191–202. doi:10.1001/archsurg.1951.01250040195008