IN A PREVIOUS communication1 we reviewed the clinical causes and the present-day methods of treatment of portal hypertension. We also discussed the physiology of the hepatic circulation, and one of us (J. K. B.) presented the results of experimental work on portal hypertension since March, 1947. This work may be summarized briefly as follows:
1. Survival After Ligation of Hepatic Artery
A. Without preparation with penicillin and streptomycin
1. Ligation close to liver caused death due to liver necrosis and gangrene of gall bladder with bile peritonitis
2. Ligation at source caused death due to liver necrosis and gangrene of gall bladder, with bile peritonitis in many instances
B. Preparation with penicillin and streptomycin
1. Ligation close to liver caused death due to liver necrosis
2. Ligation at source resulted in survival if dogs were cared for properly
II. Collateral Circulation After Ligation of Hepatic Artery at Source
A.