THE REGULAR production of progressive gastrojejunal ulcers in experimental animals when the alkaline juices of the duodenum are deviated into the intestinal tract lower down has been of great value in analyzing the pathogenesis of this disease and in evaluating certain forms of therapy. The commonly accepted explanation for the development of these ulcers holds that they are due to the digestant action of the pepsin hydrochloric acid of the gastric content coming in contact with intestinal mucosa, unprotected by the neutralizing and buffering action of the pancreatic juice, bile, and succus entericus. It is the purpose of the present communication to present data which indicate that a second, potent, ulcer-forming factor is set in motion, namely, a hypersecretion of gastric juice from the fundus and body of the stomach.
Exalto1 was actually the first to produce experimental ulcers by this method and should be given full credit for
STORER EH, OBERHELMAN HA, WOODWARD ER, SMITH CA, DRAGSTEDT LR. EFFECT OF THE EXALTO-MANN-WILLIAMSON PROCEDURE ON GASTRIC SECRETION. AMA Arch Surg. 1952;64(2):192–199. doi:https://doi.org/10.1001/archsurg.1952.01260010204009
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: