MYXOMATOUS lesions are generally accepted as being either true neoplasms or foci of mucinous degeneration. Those involving the skin are localized in a zone of dermis or subcutaneous tissue, and they usually present cystic centers with no definite cellular lining. The wall, which is indefinite in outline and is made up of collagen fibers, usually sends thin, irregular trabeculae toward the center of the cyst, producing a lace-like pattern in which mucoid material is seen. The material is probably hyaluronic acid. Although the lesions are innocuous in appearance, both grossly and microscopically, recurrence may take place repeatedly, even after complete excision of the affected area. Malignant transformation, however, has not been reported. Recurrence of the lesion usually follows excision, drainage, curettage, carbon-dioxide-snow treatment, or cauterization, but Jacox and Freedman1 noted that the tumors completely disappeared after low voltage roentgen therapy of 1,500 to 1,600 r. Patients who have pricked
PEARCE AE, WELLER RW, STEINBERG N. RECURRENT MYXOMATOUS CYST OF THE SKIN. AMA Arch Surg. 1952;64(6):835–839. doi:10.1001/archsurg.1952.01260010855015
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