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September 1952

HYPERTENSION AND ITS RELATION TO HEPATIC CIRCULATION: Effects on Arterial Pressure of Variations in the Blood Supply of the Liver in Normotensive, Hypertensive, and Cirrhotic Dogs, and in Hypertensive Patients with Portal Cirrhosis

Author Affiliations

From the Departments of Surgery, the Indianapolis General Hospital and the Indiana University Medical Center.

AMA Arch Surg. 1952;65(3):430-447. doi:10.1001/archsurg.1952.01260020444011

ONE OF us (J. K. B.) previously reported that changes in systemic blood pressure do not occur when hepatic vascular moieties are altered in the experimental animal or in man.1 This fact and the observation that portal cirrhosis is rarely associated with arterial hypertension prompted us to study the relationship of liver circulation to changes in systemic blood pressure.

The results of vagaries in hepatic arterial, portal, and hepatic venous flow on systemic blood pressure were measured in angiotonin units and correlated with manometric determinations. Combinations of venous and arterial alterations were also produced, and the corrective effects of such maneuvers, one against the other, were recorded. Three groups of dogs were studied: (a) normotensive, (b) hypertensive, and (c) cirrhotic. Two cases of Laennec's cirrhosis and ascites associated with arterial hypertension are also included in this report.

METHODS AND MATERIALS  Healthy mongrel dogs were made hypertensive by unilateral nephrectomy

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