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March 1953

EXPERIMENTAL STUDIES WITH INTRA-ARTERIAL TRANSFUSION: Overtransfusion in the Anemic Dog and the Hypoproteinemic Dog

Author Affiliations

Now at the Presbyterian Hospital, University of Illinois, Chicago (Dr. Beattie).; Fulbright Fellow from Trieste, Italy (Dr. Adovasio).; From the Department of Surgery, George Washington University School of Medicine.

AMA Arch Surg. 1953;66(3):383-385. doi:10.1001/archsurg.1953.01260030398014

IN A PREVIOUS paper1 the effects of an overtransfusion of whole blood into the femoral artery in a series of normal dogs were studied. It was found that an intra-arterial transfusion of whole blood equal to 7% of the body weight of the dog, if administered in 30 to 60 minutes, caused the death of 30% of the dogs.

In overtransfusion in 10 normal dogs the femoral venous pressure rose an average of 7 cm. of saline; the respiratory rate rose an average of 14 respirations per minute; the pulse rate fell an average of 60 beats per minute, and the blood pressure tended to fall.

The present study was undertaken to see how a dog with a lowered red blood cell count or lowered plasma proteins would respond to the same sized intra-arterial transfusion of whole blood.

METHODS  Mongrel dogs weighing about 10 kg. were used. The animals

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