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April 1953

LIVER FUNCTION AS DETERMINED BY SERUM CHOLINESTERASE ACTIVITY: Studies in Patients Undergoing Surgery on the Biliary Tract

Author Affiliations

From the H. L. Snyder Memorial Research Foundation.

AMA Arch Surg. 1953;66(4):426-433. doi:10.1001/archsurg.1953.01260030441009

THE ENZYME cholinesterase is a protein of liver origin. The concentration of cholinesterase appearing in the blood serum at any one time is a reflection of the rate of formation of the enzyme by the liver. The value of the determination of the cholinesterase activity of the blood serum as an index of liver function in various pathological states has been reported by many. Our preliminary observations on its value as a liver function test in surgical patients have been previously reported.1

This report is concerned with studies conducted on an additional 49 patients, all of whom underwent surgery on the biliary tract. In these patients serum cholinesterase levels were determined on one or more preoperative days, immediately before and immediately after the surgery performed, and on the 1st, 2d, 3d, 4th, 5th, 7th, and 10th postoperative days. Hemoglobin levels were determined simultaneously. Laboratory determinations of serum cholinesterase activity, hemoglobin content, and all other blood

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