IN A REVIEW of 1,928 consecutive thyroidectomies performed at the University of Michigan Hospital during the 15-year period from 1935 to 1950, 145 cases of malignant disease of the thyroid were found. Based on pathologic and clinical studies, groups of patients with early and with advanced carcinoma were separated for comparison, and special attention was devoted to the age of the patient, histopathology of the tumor, and cervical lymph node metastases as prognostic signs. A statement regarding therapy is included in this report.
Inasmuch as the morphologic criteria required for the diagnosis of cancer of the thyroid gland have been controversial, it should be stated that the pathologists at the University of Michigan Hospital made the diagnosis in these cases according to the criteria utilized in recognizing cancer in other tissues, namely, infiltrative growth, cellular dedifferentiation, nuclear hyperchromatism, mitotic figures, and atypical cells. Not all these features were necessarily present
CRABTREE HN, HUNTER DC. CARCINOMA OF THE THYROID: A Clinicopathologic Study. AMA Arch Surg. 1953;67(2):175–186. doi:10.1001/archsurg.1953.01260040180007
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