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December 1953


Author Affiliations

From the Departments of Pathology, Pondville Hospital (Massachusetts Department of Public Health), Walpole, Mass., and Harvard Medical School, Boston; the Cancer Research Institute, New England Deaconess Hospital, and Harvard Cancer Commission, Boston.

AMA Arch Surg. 1953;67(6):916-919. doi:10.1001/archsurg.1953.01260040929012

FOR YEARS oophorectomy has been advocated in premenopausal cases of mammary cancer as a method of arresting its growth and of increasing the survival time in a significant percentage of cases.

In this study an attempt has been made to determine whether a pathologic alteration of ovarian stroma commonly found associated with breast cancer has retarded or accelerated the malignant disease process. For this purpose the total disease durations in collected cases of untreated and mastectomized patients were compared with breast cancer cases in which the patients were also surgically castrated.

Previous investigation of 100 autopsied cases of breast cancer indicated that, regardless of the age of the patient at cancer onset, in a large majority (83%) of cases the ovaries were abnormal, being characterized by a hyperplasia of the cortical stroma, reflecting active secretion of some steroid hormone.1 Circumstantial evidence pointed to anterior pituitary hyperfunction as the cause

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