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January 1954

CHLORIDORRHEA: Syndrome Associated with Diarrhea and Potassium Deficiency

Author Affiliations

From the Department of Surgery, University of Minnesota, and the Pack Medical Foundation, New York.

AMA Arch Surg. 1954;68(1):105-116. doi:10.1001/archsurg.1954.01260050107014

THE ASSOCIATION of potassium deficiency with diarrhea is rather common, the potassium deficiency being secondary to the diarrhea.

Usually diarrhea is associated with acidosis because of the excess of base over anions in large bowel excretions. The patient who forms the basis of this report presented the paradoxical picture of severe diarrhea associated with alkalosis. The unusual status of an excess of chloride over base in the diarrheal stool of this patient with an associated hypokalemic alkalosis and severe clinical sequelae has many features in common with the unusual instances of infants with congenital alkalosis and diarrhea presented by Gamble and his associates17 and Darrow.10 This report describes the results of studies performed upon the patient and the effects of different therapeutic modalities upon the entity. The chemical methods employed have been reported.* Stool electrolytes were determined by the method of Wallace.

REPORT OF A CASE  A 66-year-old white man was admitted to the hospital on

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