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September 1954

MALIGNANT MELANOMA: Treatment and End-Results in Two Hundred and Twenty-Five Cases

Author Affiliations

From the Department of Surgery, Northwestern University Medical School, Chicago, and the Veterans Administration Hospital, Hines, Ill.; Dr. William L. McNamara, Chief of the Department of Pathology, reviewed many of the microscopic preparations of tissue from patients included in this study.; Mr. Phillip W. Zinkgraf, Chief Medical Statistician, and Miss Hazel Hanley, Director of the Tumor Registry, Hines Hospital, gave valuable help in the preparation of this paper.

AMA Arch Surg. 1954;69(3):385-392. doi:10.1001/archsurg.1954.01270030113010

IT IS NOW generally appreciated that the treatment of operable malignant melanoma is surgical. However, there is still much uncertainty about some of the details of surgical treatment. For instance, when one excises a malignant melanoma, how wide should the excision be? Should one dissect the regional lymph nodes in all cases of melanoma of the skin or only in those cases in which the nodes seem to contain metastases? Should an amputation be done in preference to wide excision in treating melanoma of the extremities? In an attempt to crystallize our ideas regarding some of these questions, we have recently reviewed the cases seen at the Veterans Administration Hospital, Hines, Ill., prior to July, 1948.

MATERIAL STUDIED  The diagnosis of malignant melanoma was made in 294 cases between December, 1930, and July, 1948. However, material was available for microscopic study in only 248 of these cases. This tissue was

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