THE STEADILY increasing laboratory and clinical evidence that ulceration in the upper gastrointestinal tract is due to the corrosive effect of the gastric content is now so complete that it is no longer permissible to state that the cause of duodenal and gastric ulcers is unknown. Many problems, however, remain, and one of these has to do with the sites of predilection for these lesions. Ulcers near the stoma of a gastrojejunostomy or gastroduodenostomy may be accounted for since there is now proof that the normal duodenal and jejunal mucosa has less resistance to the digestive action of pure gastric juice than is the case with the gastric mucosa. Ulceration in the lower end of the esophagus and in the ileum opposite the entrance of Meckel's diverticulum containing heterotopic gastric mucosa is probably due to similar reasons. Why, however, do the large majority of ulcers occur along the lesser curvature
Dragstedt LR. SITES OF PEPTIC ULCERATION. AMA Arch Surg. 1955;70(3):326–327. doi:10.1001/archsurg.1955.01270090004002
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