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March 1955

Utilization of Glucose, Fructose, and Invert Sugar: Comparison in Diseases of the Liver and Pancreas

Author Affiliations

Columbus, Ohio
From the Department of Surgery and the Surgical Laboratories, Ohio State University College of Medicine.

AMA Arch Surg. 1955;70(3):428-435. doi:10.1001/archsurg.1955.01270090106024

Although numerous reports dealing with the comparative utilization of infused glucose, fructose, and invert sugar have appeared in the recent surgical and biochemical literature, the results of these studies are still equivocal. Certain investigations have indicated that fructose and invert sugar are superior to glucose for parenteral feeding purposes; others have suggested the reverse.

In previous studies Weichselbaum,1 Elman and Lund, using infusion rates of 0.6 to 2 gm. per kilogram per hour, reported that after fructose the urine contained little sugar as compared with glucose. The diuretic effect was less pronounced with fructose. Lawton and Curreri and Gale found that a 10% solution of invert sugar can be given more rapidly and is more completely utilized than glucose.2 They also noted a lessened diuretic effect with invert sugar. In this study 1 liter of solution was infused at a rate of 1.5 gm. per kilogram body weight

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