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April 1955

Experimental Segmental Pericarditis: Its Bearing on Clinical Pericardiectomy

Author Affiliations

San Francisco
From the Laboratory for Surgical Research, Stanford University School of Medicine. This work was supported by a grant from the Life Insurance Medical Research Fund.; Boyd Foundation (Long Beach, Calif.) Fellow in Thoracic Surgery (Dr. Parsons).

AMA Arch Surg. 1955;70(4):479-490. doi:10.1001/archsurg.1955.01270100005003

The wide diversity of opinion as to where and how much of the pericardium should be removed from the constricted heart in the surgical treatment of constrictive pericarditis has been the subject of much discussion and some controversy by many authors.* A preliminary report of certain significant experimental studies was presented to the Surgical Forum of the American College of Surgeons in 1950.26

Experiments have been many and varied.† In an excellent report, Isaacs, Carter, and Haller23 presented highly important studies in which segmental constrictive pericarditis was produced by suturing the pericardium to the myocardium to form a pericardial pocket over the area of future constriction and introducing a copolymer vinyl acetate and vinyl chloride cast into the pocket to cause scarring. They presented a concept of the pathologic physiology of constrictive pericarditis supported by abundant laboratory findings in which constriction of either or both ventricles is held

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