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October 1955

Intravenous Cholecystography with a New Medium: Experience with Sodium Acetnzoate (Urokon Sodium) Seventy Per Cent

Author Affiliations

Department of Radiology, Albert Einstein Medical Center, Northern Division.

AMA Arch Surg. 1955;71(4):620-622. doi:10.1001/archsurg.1955.01270160146019

Intravenous cholecystography has not been generally utilized because of fear of severe constitutional reaction. Recently, it has been recognized that, with the refined technique used in preparing iodine solutions for intravenous cholecystography, this former objection is no longer valid. This paper reviews our experience with sodium acetrizoate (Urokon sodium) 70% (developed by the Mallinckrodt Chemical Works) as a cholecystographic agent.

Sodium acetrizoate 70% is a sodium salt of 3-acetylamino-2,4,6-triiodobenzoic acid. It is among the least toxic materials in general use as an intravenous contrast medium. This compound has the following structural formula and contains 65.8% iodine per molecule, or 23.03 gm. of iodine per 50 cc.

PREPARATION AND TECHNIQUE  Preliminary catharsis, preferably with castor oil, should be carried out to clear the colon of gas and fecal content. The examination is begun with the patient fasting. One to two cubic centimeters of sodium acetrizoate 70% is injected intravenously, and, if