It is generally thought that benign peptic ulcer of the gastrointestinal tract occurs when there is a relative excess of acid gastric juice over the neutralizing and buffering mechanisms present. In most patients with duodenal ulcer this situation obtains because of hypersecretion of acid gastric juice of nervous origin.1 This hyperstimulation is transmitted from the central nervous system to the stomach by way of the vagus nerves; hence, vagotomy abolishes this pathologic mechanism and allows healing of these lesions.
The gastrointestinal tract, however, is not selective and will succumb to the corrosive action of gastric juice from whatever origin. Thus, in experimental animals the administration of histamine in yellow wax (beeswax) will regularly produce peptic ulceration.2 In dogs the transplantation of the gastric antrum into the colon results in hyperfunction of the antral "gastrin" mechanism.3 Peptic ulcers appear in a large percentage of such animals.4
WOODWARD ER, STEVENS GA, ROBERTSON C. The Role of the Antrum in Surgery for Duodenal Ulcer. AMA Arch Surg. 1956;72(6):1003–1008. doi:https://doi.org/10.1001/archsurg.1956.01270240115016
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: