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July 1956

Gastrocardiopexy: An Experimental Study

Author Affiliations

From the Department of Surgery of the University of Chicago. This work has been aided by grants from the Otho S. A. Sprague Memorial Institute and the Douglas Smith Foundation for Medical Research of the University of Chicago.

AMA Arch Surg. 1956;73(1):1-5. doi:10.1001/archsurg.1956.01280010003001

In 1951, Dragstedt, Oberhelman, and Smith1 reported that transplantation of the antrum of the stomach into the transverse colon as a diverticulum in dogs produced a sustained hypersecretion of gastric juice with typical peptic ulcer formation. This observation prompted a study of the factors involved in producing this hyperactivity of the endocrine function of the antrum. It was soon found that tension within the antrum, especially that provoked by the hyperperistalsis associated with pyloric stenosis, was an even more profound stimulus to the endocrine function of the antrum than was contact with food or the primary products of digestion.2 In subsequent experiments Heidenhain pouches were prepared in dogs for the quantitative collection of gastric secretion by methods previously described from this laboratory,3 and later the antrum was transplanted as a diverticulum into the urinary bladder. It was hoped that the motility of the bladder associated with micturition

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