In 1951, Dragstedt, Oberhelman, and Smith1 reported that transplantation of the antrum of the stomach into the transverse colon as a diverticulum in dogs produced a sustained hypersecretion of gastric juice with typical peptic ulcer formation. This observation prompted a study of the factors involved in producing this hyperactivity of the endocrine function of the antrum. It was soon found that tension within the antrum, especially that provoked by the hyperperistalsis associated with pyloric stenosis, was an even more profound stimulus to the endocrine function of the antrum than was contact with food or the primary products of digestion.2 In subsequent experiments Heidenhain pouches were prepared in dogs for the quantitative collection of gastric secretion by methods previously described from this laboratory,3 and later the antrum was transplanted as a diverticulum into the urinary bladder. It was hoped that the motility of the bladder associated with micturition
DRAGSTEDT LR, RAGINS H, LYON ES, DRAGSTEDT LR. Gastrocardiopexy: An Experimental Study. AMA Arch Surg. 1956;73(1):1–5. doi:10.1001/archsurg.1956.01280010003001
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