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September 1956

Experimental Repair of Cardiac Septal Defects: Use of Hypothermia with Coronary and Carotid Artery Perfusion

Author Affiliations

From the Department of Surgery, Indiana University School of Medicine, Indianapolis. Aided by grants from the National Heart Institute, The United States Public Health Service; the Indiana Heart Foundation; the James Whitcomb Riley Memorial Association, and by a contract between the Office of Naval Research, the United States Navy, and Indiana University.

AMA Arch Surg. 1956;73(3):485-492. doi:10.1001/archsurg.1956.01280030111013

In the last few years, open cardiac surgery has been employed with increasing frequency for the direct repair of intracardiac defects. Its main use has been in cases of atrial septal defect and pulmonic stenosis. Recently, however, the repair of ventricular septal defects has been carried out experimentally and clinically. Two techniques have been employed for this purpose, the pump oxygenator and hypothermia. We have recently studied several methods which have rendered possible safe open cardiac surgery in the experimental animal with very low incidence of ventricular fibrillation and a high survival rate.* In a series of dogs protected by sinoauricular node blockade with procaine, we have been able to produce and repair ventricular septal defects with survival of all of the animals.6 We have recently demonstrated that the safe period of vena caval occlusion can be appreciably extended by coronary and carotid artery perfusion with oxygenated blood.7

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