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November 1956

Islet-Cell Adenoma: Report of a Case with a Brief Review of Diagnostic Criteria

Author Affiliations

From Thorndike Memorial Labs, 2nd & 4th Medical Services (Harvard) Boston City Hospital and Dept. of Medicine, Harvard Medical School, Diabetes Service, Boston City Hospital and Fifth Surgical Service, Boston City Hospital.; Formerly Research Fellow in Medicine, Thorndike Memorial Laboratory, Boston City Hospital and Harvard Medical School (Dr. Cohen and Dr. Vance); formerly Resident in Surgery, Fifth, Surgical Service, Boston City Hospital (Dr. Senter).

AMA Arch Surg. 1956;73(5):801-803. doi:10.1001/archsurg.1956.01280050069013

I. Introduction  Spontaneous hyperinsulinism due to islet-cell tumors, while not a common condition, is one of which the medical profession is becoming increasingly aware, due to its dramatic symptomatology and the complete cure that may be effected by operative removal.The typical symptom-complex was reported by Harris,1 in 1924, the first surgical proof of hyperinsulinism by the Mayo Clinic,2 in 1927, and the first surgical cures by Howland,3 in 1929, and Cushing,4 in 1930. The medical and surgical aspects have been extensively reviewed (Crain and Thorn [1949],5 Lopez-Kruger and Dockerty [1947],6 Howard, Moss, and Rhoads [1950].7)It is not proposed to review the multiplicity of causes of spontaneous hypoglycemia, of which some 25-30 have been listed by Conn.8 However, it is well to note that over 80% of the cases are caused by (a) functional hypoglycemia, (b) organic hyperinsulinism, and (c) hepatogenic