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January 1957

Effects of Intra-Arterial Injection of Iodine Contrast Media on the Kidney of the Dog

Author Affiliations

Durham, N. C.
From the Departments of Surgery, Pathology, and Biochemistry, Duke University School of Medicine.

AMA Arch Surg. 1957;74(1):39-49. doi:10.1001/archsurg.1957.01280070043005

The literature pertaining to the development of aortography and to the occasional occurrence of serious injury of the spinal cord, mesenteric circulation, or kidneys has been referred to in previous reports from our laboratories1,2 and has been reviewed more recently by McAfee and Willson.3 Many authors emphasize the potential toxicity of contrast media to the kidney and the spinal cord. Our first report described an experimental method for producing injury of the spinal cord in dogs and compared the toxicity of two contrast media. Studies have continued in dogs in an attempt to standardize a similar technique for producing injury of a kidney. Idbohrn and Berg4 have investigated injury of the rabbit's kidney by intra-arterial injection of contrast media and have reviewed earlier literature on experimental renal injury.

In our first study two contrast media were compared, sodium acetrizoate (Urokon Sodium) and iodopyracet (Diodrast). In the present