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January 1957

The Intrathoracic Use of Au198 After Pneumonectomy: A Preliminary Study

Author Affiliations

Birmingham, Ala.
From the Radioisotope Unit of the Veterans Administration and the Departments of Surgery and Medicine, Medical College of Alabama.

AMA Arch Surg. 1957;74(1):145-148. doi:10.1001/archsurg.1957.01280070149019

Bronchogenic carcinoma is increasing in frequency, and the five-year survival rate following all forms of therapy remains disappointingly low. One of the reasons for this latter situation is the presence of tumor cells in the mediastinal lymph nodes, especially those of the opposite side, not customarily removed even in the "radical" pneumonectomy. In the attempt to deal with these nodes by radiation, it seemed feasible to place a radioactive substance in the empty hemithorax immediately postoperatively, in the hope that the substance would be picked up by the pleural and mediastinal lymphatics and carried to the mediastinal nodes. The obvious choice of a test substance was colloidal Au198, since this substance has been used in the pleural space,1 delivers 95% short-range (mean penetration 0.38 mm.) beta radiation, and has been shown to be carried to mediastinal nodes after intrabronchial instillation.2 In addition to intrabronchial and intrapleural administration,

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