It has been shown that ulcers resulting from deviation of duodenal, pancreatic, and biliary secretions are due primarily to the corrosive action of undiluted and unneutralized gastric juice. A clear example of this corrosive effect is observed in those cases of Meckel's diverticulum containing heterotopic gastric mucosa with a peptic ulcer in the ileum adjacent to the entrance of the diverticulum. This corrosive action of gastric juice was demonstrated experimentally by Matthews and Dragstedt * by anastomosing Pavlov pouches to the ileum of dogs. Stoma ulcers occurred in 100% of the cases. A similar result was obtained by Barry and Florey,3 working with cats and pigs. In the experiments of Gage, Ochsner, and Hosoi4 ulcers occurred in only 71% of the animals when the Heidenhain pouches were constructed from the lesser curvature of the stomach. This can be explained by the greater acidity of the gastric juice secreted from
BRAVO JL, BARCENA J, BAUGH CM, et al. Experimental Meckel's Diverticulum: The Production of Peptic Ulcers by the Internal Drainage of a Heidenhain Pouch. AMA Arch Surg. 1957;74(2):255–258. doi:https://doi.org/10.1001/archsurg.1957.01280080109017
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: