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February 1957

Experimental Meckel's Diverticulum: The Production of Peptic Ulcers by the Internal Drainage of a Heidenhain Pouch

Author Affiliations

From the Department of Surgery of the University of Chicago.

AMA Arch Surg. 1957;74(2):255-258. doi:10.1001/archsurg.1957.01280080109017

It has been shown that ulcers resulting from deviation of duodenal, pancreatic, and biliary secretions are due primarily to the corrosive action of undiluted and unneutralized gastric juice. A clear example of this corrosive effect is observed in those cases of Meckel's diverticulum containing heterotopic gastric mucosa with a peptic ulcer in the ileum adjacent to the entrance of the diverticulum. This corrosive action of gastric juice was demonstrated experimentally by Matthews and Dragstedt * by anastomosing Pavlov pouches to the ileum of dogs. Stoma ulcers occurred in 100% of the cases. A similar result was obtained by Barry and Florey,3 working with cats and pigs. In the experiments of Gage, Ochsner, and Hosoi4 ulcers occurred in only 71% of the animals when the Heidenhain pouches were constructed from the lesser curvature of the stomach. This can be explained by the greater acidity of the gastric juice secreted from