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February 1957

Antibiotic TherapyTreatment of Infectious Complications of Surgery of the Gallbladder and Bile Ducts

AMA Arch Surg. 1957;74(2):259-265. doi:10.1001/archsurg.1957.01280080113018

Infections sometimes complicate operations on the gallbladder and bile ducts and require prompt and effective treatment. The purpose of this paper is primarily to outline the antibiotic treatment of such infections and to report the observations made in a number of cases encountered at the Mayo Clinic.

Principles of Antibiotic Treatment  The principles of successful management of infections complicating operations on the gallbladder and biliary ducts include (1) identification of the causative organisms when possible, (2) restoration of any hematologic and metabolic deficits and correction of any other condition that predisposes to continued infection, (3) elimination of factors preventing drainage of the wound and free access of antibiotic agents to the site of infection, and (4) careful selection and rational administration of antibiotic agents.The principles of antibiotic therapy may easily be abused. If treatment with antibiotics is effective, it almost always is rapidly so, when given correctly. It is