The increasing incidence of collagen diseases and their surgical complications led us to believe that a review of some of the facts concerning these and a report of a collection of some local cases with such complications might be of interest. The frequency of occurrence of lupus erythematosus alone is now estimated to be about one-half that of rheumatic fever.8 It is probable that an actual increase of these diseases has occurred owing to exacerbations of otherwise latent cases caused by minute quantities of drugs administered to fowl and animals and transmitted to humans through meat, eggs, and milk, since hypersensitivity and allergy, while not the sole cause, are important factors in these conditions. The
CARLSON E, HUDSON JP. Surgical Complications of, and Splenectomy for, Collagen Diseases. AMA Arch Surg. 1957;74(3):381–393. doi:https://doi.org/10.1001/archsurg.1957.01280090079011
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