The literature on the local use and effect of hydrocortisone acetate (Kendall's Compound F; 17-hydroxycorticosterone-21-acetate; Cortril acetate [Pfizer]) has grown to abundant proportions since Kendall et al. delivered their first laboratory investigative report in 1948 and after Hollander et al.,1 in 1951, reported good results following the local use of compound F in the knee joint of a patient afflicted with rheumatoid arthritis.
Some confusion arose from the early reports as to the oral use of hydrocortisone. The parenteral use of the drug was thought to give satisfactory results, but Hollander demonstrated a much higher degree of prompt relief following local injection of the drug into the various involved joints.
Conn et al.2 reported that all of the metabolic changes brought about by corticotropin (ACTH) were reproduced by the injected hydrocortisone. Other workers.also drew enthusiastic conclusions as to the effectiveness of the intra-articular use of hydrocortisone for
FRANKEL CJ, WEBSTER DK, HAMILTON TM. Experimental Use of Hydrocortisone in the Traumatized Knees of Rabbits. AMA Arch Surg. 1957;74(3):399–404. doi:10.1001/archsurg.1957.01280090097013