The growth of vascular tumors in response to hormonal stimulation is a well-documented and generally accepted fact. The development of nevus-araneous-like hemangiomata associated with the high hormonal blood levels of pregnancy has been described by Walsh and Becker, Forman, Zeisler, Feldman, and others.
The "pregnancy tumor," frequently mentioned in the dental literature and described by Thoma and Miller as a fibroangioma or a form of epulis, is another example of the growth of vascular elements in response to rising hormonal titers. Neither the telangiectasis nor "pregnancy tumors" are true neoplasmas, but they do represent cyclic hyperplasia of vascular tissues.
The effect of endocrine stimulation on cavernous hemangiomas, true neoplasmas, in contradistinction to the aforementioned hyperplasias, remains a controversial issue. Although Kitlowski has described flare-ups of these tumors at the time of puberty and of menopause and during pregnancy, Johnson, Ghormley, and Dockerty in a recent review of hemangiomas of the
BOLEY SJ, MORSE WE. Hormonally Influenced Hemangioma. AMA Arch Surg. 1957;74(3):482–484. doi:10.1001/archsurg.1957.01280090180024
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