This study was undertaken with the purpose of determining whether acute pancreatitis could be induced in dogs by ligation of the pancreatic ducts in face of an actively secreting gland and what bearing an associated disturbance in the blood supply of the pancreas had on the lesions so obtained. We were also interested in finding out whether a transitory disturbance of the blood supply of the pancreas produced by stimulation of the left splanchnic nerve would induce experimental pancreatitis, as had been reported by Mallet-Guy and others.1-3 Very little evidence other than the recent experimental work of Lium and Maddock4 has been offered to substantiate the hypothesis that acute pancreatitis may be due to obstruction of the outflow of pancreatic juice into the duodenum. The bulk of evidence from experimental studies is that ligation of the pancreatic ducts in experimental animals does not suffice to induce acute pancreatitis
MENGUY RB, HALLENBECK GA, BOLLMAN JL, GRINDLAY JH. Ductal and Vascular Factors in Etiology of Experimentally Induced Acute Pancreatitis. AMA Arch Surg. 1957;74(6):881–889. doi:https://doi.org/10.1001/archsurg.1957.01280120059006
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: