Experimental investigation of the effect of the presence of pancreatic ferments in the biliary system was first reported in 1917 by Blad,1 who injected duodenal juices into the gallbladders of dogs during his study of the pathogenesis of nonperforative bile peritonitis. Since then several investigators have injected pancreatic juice into the gallbladder and bile duct system, with varying results.2-5 Bisgard and Baker6 ligated the common bile duct of young goats near the duodenum, resulting in a mixing of bile and pancreatic enzymes in both the gallbladder and the pancreas and producing cholecystitis and pancreatitis. They observed that pancreatic ferments alone did not produce inflammation of the biliary tract, but when pancreatic enzymes were in the gallbladder, together with a condition of stasis, cholecystitis invariably developed. More recently Reid7 anastomosed an isolated segment of duodenum containing the main pancreatic duct to the gallbladder in dogs with and
NAJARIAN JS, HINE DE, WHITROCK RM, McCORKLE HJ. Effect of Pancreatic Secretions on the Gallbladder. AMA Arch Surg. 1957;74(6):890–899. doi:https://doi.org/10.1001/archsurg.1957.01280120068007
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