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June 1957

Capillary Resistance in Response to Anesthesia and Surgery: Special Reference to Cardiac Arrest

Author Affiliations

Departments of Surgery, Pediatrics, and Biochemistry, Creighton University School of Medicine.

AMA Arch Surg. 1957;74(6):908-910. doi:10.1001/archsurg.1957.01280120086009

Recent studies pioneered by Moore and his associates1 resulted in a rapid progress toward a better understanding of the pathophysiologic changes that develop during surgery and surgical convalescence. Owing to its complexity, the problem has been attacked from many sides: by studying the metabolic and hemodynamic changes, the hematologic response, or the endocrine situation. In our work a new approach has been attempted which may lead to further contribution to this problem. It is based on studies of the capillary resistance.

Previous studies during the last five years have shown that the measuring of capillary resistance is not merely a test for bleeding tendency but is possessive of greater significance. Capillary resistance is subject to endocrine influence.2,3 Certain corticoids, vasopressin, and oxytocin increase capillary resistance, while the somatotropic hormone decreases it. Histamine also was found to decrease capillary resistance. Capillary resistance shows typical changes following stressful stimuli.4-6

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