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September 1957

Observations on a New Anesthetic Agent, Fluothane

Author Affiliations

Iowa City
From the Division of Anesthesiology, Department of Surgery, State University of Iowa College of Medicine.

AMA Arch Surg. 1957;75(3):339-341. doi:10.1001/archsurg.1957.01280150029003

Fluothane (2-b r o m o-2-chloro-1,1,1-trifluoroethane) is a potent, nonexplosive anesthetic agent recently developed by Imperial Chemical Industries of England. It is a volatile liquid having the chemical structure indicated in the Figure. Johnstone1 published the first clinical report of its use in September, 1956; another, by Bryce-Smith and O'Brien,2 appeared in December, 1956. In addition to the properties already mentioned, Fluothane was stated to possess a not unpleasant odor, which, in addition to its great potency, allowed for short, pleasant inductions, usually with little or no excitement. Excellent muscular relaxation, rapid recovery, and a low incidence of nausea and emesis were also reported. Although hypotension accompanied by bradycardia was said to occur, the impression gained from the available information was sufficiently encouraging to prompt an investigation of this new anesthetic agent.

The purpose of this report is to present some clinical observations on the first 220

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