Fluothane (2-b r o m o-2-chloro-1,1,1-trifluoroethane) is a potent, nonexplosive anesthetic agent recently developed by Imperial Chemical Industries of England. It is a volatile liquid having the chemical structure indicated in the Figure. Johnstone1 published the first clinical report of its use in September, 1956; another, by Bryce-Smith and O'Brien,2 appeared in December, 1956. In addition to the properties already mentioned, Fluothane was stated to possess a not unpleasant odor, which, in addition to its great potency, allowed for short, pleasant inductions, usually with little or no excitement. Excellent muscular relaxation, rapid recovery, and a low incidence of nausea and emesis were also reported. Although hypotension accompanied by bradycardia was said to occur, the impression gained from the available information was sufficiently encouraging to prompt an investigation of this new anesthetic agent.
The purpose of this report is to present some clinical observations on the first 220
PITTINGER CB, CULLEN SC, WATLAND DC. Observations on a New Anesthetic Agent, Fluothane. AMA Arch Surg. 1957;75(3):339–341. doi:10.1001/archsurg.1957.01280150029003