In the appraisal of the patient with cancer before, during, or after treatment, it is important to know whether or not metastasis to the skeleton has occurred. If roentgenographic survey of the bones is negative or equivocal, any other test which may shed light in this regard may be of great help in certain instances. Several reports have suggested that bone-marrow examination may reveal the presence of metastatic cancer cells. The first such report was made in 1936 by Rohr and Hegglin, from Zurich, Switzerland.8 Since that time various series of cancer patients have been so tested, with positive findings ranging from 5% to 65% (Table 1). In spite of these reports, most of which are reported in journals of hematology or internal medicine, the examination is not often included in the evaluation of the cancer patient. We felt that further investigation was indicated and that the findings should
ANDAY GJ, SCHMITZ RL, NELSON PA. Metastatic Cancer Cells in Bone Marrow: Their Demonstration by Aspiration Biopsy. AMA Arch Surg. 1957;75(4):590–597. doi:https://doi.org/10.1001/archsurg.1957.01280160100013
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